In a landmark achievement for autonomous artificial intelligence, SakanaAI has unveiled AI Scientist-v2, a groundbreaking system capable of independently conducting scientific research from hypothesis generation through peer-reviewed publication. Unlike its predecessor, AI Scientist-v1, which relied on human-authored templates, AI Scientist-v2 operates with complete autonomy using progressive agentic tree search. The system operates through ideation, experimentation, analysis, and writing stages. It supports GPT-4o and Claude 3.5 Sonnet through Amazon Bedrock. The system requires controlled sandbox environments due to risks with LLM-written code execution. Costs approximately -20 per research run using Claude 3.5 Sonnet. AI Scientist-v2 marks a significant milestone toward fully autonomous scientific discovery.